What happens when Schwann cells are exposed to Mycobacterium leprae – A systematic review
نویسندگان
چکیده
Mycobacterium leprae, the pathogen that causes human leprosy, has a unique affinity for infecting and persisting inside Schwann cells, principal glia of peripheral nervous system. Several studies have focused on this intricate host-pathogen interaction as an attempt to advance current knowledge mechanisms governing nerve destruction disease progression. However, during chronic course leprosy neuropathy, cells can respond internalize both live dead M. leprae bacilli-derived antigens, may result in divergent cellular pathobiological responses. This also distinctly contribute tissue degeneration, failure repair, inflammatory reactions, fibrosis, hallmarks disease. Therefore, present study systematically searched published leprae-Schwann cell vitro summarize findings provide discussion dynamics following challenge with bacilli.
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ژورنال
عنوان ژورنال: IBRO neuroscience reports
سال: 2023
ISSN: ['2667-2421']
DOI: https://doi.org/10.1016/j.ibneur.2023.05.009